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Auto‐immunization with acute leukemia cells: Demonstration of increased lymphocyte responsiveness
Author(s) -
Gutterman J. U.,
Mavligit G.,
McCredie K. B.,
Freireich E. J.,
Hersh E. M.
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110303
Subject(s) - immunization , leukemia , immunology , lymphocyte , medicine , immune system , streptolysin , biology , bacterial protein , bacteria , genetics
Nine patients with adult acute leukemia were autoimmunized with 10 8 and/or 10 6 non‐irradiated leukemia cells during remission. Six of nine receiving 10 8 cells demonstrated a 100% or greater increase in in vivo lymphocyte blastogenic response to their own leukemia cells measured 7 days after immunization. In four responders, increased blastogenesis was noted only in autologous serum, but not in allogeneic serum. Only one of four demonstrated increased lymphocyte blastogenic response in autologous serum after immunization with 10 6 cells. The increased immune response was always accompanied by significantly increased blastogenic response to phytohemagglutinin (PHA) and/or Streptolysin‐O (SLO). Three patients studied 28–42 days following immunization showed a persistent increase in lymphocyte blastogenic response to leukemia cells, but the response to PHA and SLO had returned to pre‐immunization levels.