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Study of the cellular proliferation kinetics of friend leukemia
Author(s) -
SmadjaJoffe Florence,
Jasmin C.,
Malaise E. P.,
Bournoutian Catherine
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110208
Subject(s) - spleen , mitosis , leukemia , biology , cell cycle , microbiology and biotechnology , immunology , apoptosis , cancer research , andrology , medicine , genetics
We have studied the kinetic parameters of the polycythemic variety of Friend leukemia using DBA 2 mice inoculated with the virus. Proliferation was mainly observed in the erythroblasts of the spleen. The mean duration of the mitotic cycle is 7.6 h and the majority of erythroblasts are in active stages of the cell cycle. The proliferation rate is unaffected even during the hours preceding death. The multiplication of erythroblasts in the spleen results in three different phenomena: 1/3 of the erythroblasts produce short‐lived erythrocytes; a very small fraction (1/20) of the proliferation accounts for the slow growth of the spleen and the progressive invasion of the liver and the blood; 2/3 disappear, and this loss is apparently due to massive splenic cellular death.