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The effect of splenectomy on fibrosarcoma “metastases” in lungs of mice
Author(s) -
Milas Luka,
Mujagic Hamza
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110122
Subject(s) - fibrosarcoma , splenectomy , thymectomy , spleen , medicine , pathology , lung , neoplasm , methylcholanthrene , immunology , biology , carcinogen , myasthenia gravis , genetics
Cells of a methylcholanthrene‐induced fibrosarcoma, injected intravenously into syngeneic C57Bl mice, generated tumour nodules (“metastases”) in the lungs. The number of tumour nodules was reduced in recipients whose spleens had been previously removed. This effect of splenectomy was specific (thymectomy did not affect the number of pulmonary metastases), and was greater if fewer tumour cells were injected. It was also observed that active immunization against the fibrosarcoma caused stronger inhibition of pulmonary metastases in splenectomized than in sham‐operated mice.