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Specific “arming” of normal lymph‐node cells by sera from tumor‐bearing mice
Author(s) -
Pollack Sylvia
Publication year - 1973
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910110116
Subject(s) - lymph node , cytotoxic t cell , lymph , methylcholanthrene , in vivo , cytotoxicity , in vitro , pathology , intraperitoneal injection , medicine , tumor cells , neoplasm , cancer research , immunology , biology , carcinogen , biochemistry , genetics , microbiology and biotechnology
Lymph‐node cells of non‐sensitized mice were “armed” (i.e. made specifically cytotoxic) by exposure in vivo to passively transferred sera from tumor‐bearing mice. Four hours after an intraperitoneal injection of antitumor serum, the lymph nodes were removed from recipient mice and the activity of the lymph‐node cells was tested on tumor cells in an in vitro microcytotoxicity test. Specific cytotoxicity was demonstrated to the respective target tumors (Moloney virus or 3‐methylcholanthrene‐induced sarcoma) carried by the tumor‐bearing serum donors.