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The formation of variants with a reversion of properties of transformed cells. VIII. in vitro limited life span of variants isolated from tumors
Author(s) -
Rabinowitz Zelig,
Sachs Leo
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100320
Subject(s) - reversion , life span , in vitro , biology , phenotype , carcinogen , span (engineering) , cell culture , microbiology and biotechnology , genetics , gene , evolutionary biology , civil engineering , engineering
Cells transformed after treatment with the chemical carcinogen dimethylnitrosamine (DMNA) inoculated into animals, can produce tumors containing variants with a reversion of in vitro properties of transformed cells. In contrast to variants from tumors produced by polyoma‐transformed cells, 83% of the variants in tumors from DMNA‐transformed cells had again acquired, like normal cells, a limited life‐span. in vitro. Seventeen % of the variants escaped the termination of their life‐span by re‐reverting to the transformed state.