Premium
Cell‐mediated reaction against tumors induced by oncornaviruses. I. Kinetics and specificity of the immune response in Murine sarcoma virus (MSV)‐induced tumors and transplanted lymphomas
Author(s) -
Leclerc J. C.,
Gomard E.,
Levy J. P.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100318
Subject(s) - immune system , antigen , cytotoxic t cell , sarcoma , biology , neoplasm , serology , spleen , cancer research , immunology , lymphoma , virology , lymphatic system , microbiology and biotechnology , antibody , pathology , in vitro , medicine , biochemistry , genetics
Abstract Anti‐tumour cell‐mediated immune reactions were studied by the chromium release test (CRT) in mice bearing autochtonous Murine Sarcoma Virus (MSV)‐induced sarcomas or syngeneic transplants of lymphomas with various antigenic specificities. Cytotoxic lymphoid cells were detected during tumor growth, but disappeared rapidly after day 13–15 in “progressors”, and more slowly in mice which were able to reject the tumor (“regressors”). The level of cytolytic activity of lymphoid cells in the spleen of “regressors” did not parallel the immune protection. No blocking of the cytotoxic activity of lymphoid cells was detected in CRT using either “progressor”, or “regressor” sera. The discrepancies which exist between these results and those which were obtained in the same tumor system by colony inhibition test or microcytotoxicity assay may suggest that different phenomena, possibly involving different lymphoid cell populations, were studied by the various methods. The antigenic specificity of the immune reactions which were evidenced by the CRT was not identical to those revealed by serological methods, cross‐reactivity being regularly observed in CRT between FMRGi+ and G+lymphomas.