Evaluation of the carcinogenic activity of the hydroxymethyl derivatives of 7,12‐dimethylbenz(A) anthracene by an  in vitro‐in vivo  technique | Zendy

Flaks A. | Zendy; Hamilton J. M. | Zendy; Clayson D. B. | Zendy; Sims P. | Zendy

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Evaluation of the carcinogenic activity of the hydroxymethyl derivatives of 7,12‐dimethylbenz(A) anthracene by an in vitro‐in vivo technique

Author(s) -

Flaks A.,

Hamilton J. M.,

Clayson D. B.,

Sims P.

Publication year - 1972

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910100313

Subject(s) - anthracene , 7,12 dimethylbenz[a]anthracene , carcinogen , hydroxymethyl , in vitro , in vivo , chemistry , hydrocarbon , biochemistry , toxicology , stereochemistry , organic chemistry , biology , dmba , carcinogenesis , gene , microbiology and biotechnology

7,12‐Dimethylbenz(a)anthracene and three of its metabolites were tested for carcinogenic activity by in vitro incubation with murine pulmonary tissue for 2 days followed by implantation of the explants into isologous mice. 7‐Hydroxymethyl‐12‐methylbenz(a) anthracene and 12‐hydroxymethyl‐7‐methylbenz(a) anthracene were as potently carcinogenic as the parent hydrocarbon but 7,12‐dihydroxymethylbenz(a)‐anthracene was inactive. These results are discussed in the light of current theories of metabolic activation of the hydrocarbon.

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