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Embryonic antigen expression in chemically induced rat hepatomas and sarcomas
Author(s) -
Baldwin R. W.,
Glaves Dorothy,
Vose B. M.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100202
Subject(s) - antigen , embryonic stem cell , carcinogen , cytotoxic t cell , cytotoxicity , immunofluorescence , biology , lymph node , cancer research , pathology , microbiology and biotechnology , immunology , antibody , in vitro , medicine , biochemistry , gene
Embryonic antigens were detected at the surface of carcinogen‐induced rat hepatoma and sarcoma cells by their reactivity in membrane immunofluorescence tests with sera from multiparous rats. These sera also showed complement‐dependent cytotoxicity for plated target tumour cells, and lymph‐node cells from multiparous rats were similarly cytotoxic when compared with the effects of cells from normal virgin age‐matched controls. These embryonic antigens could be demonstrated on embryonic cells but not on cultured normal adult rat liver cells or lung fibroblasts. The tumour‐associated embryonic antigens were shown to be common to both tumour types and so differ from the individually distinct antigens associated with these carcinogen‐induced tumours which play a major role in immune rejection responses.