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Studies on type‐H virus‐like particles in hamster: Their role in oncogenesis
Author(s) -
Césarini J. P.,
de Micco C.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100123
Subject(s) - hamster , rous sarcoma virus , carcinogenesis , virology , biology , virus , baby hamster kidney cell , carcinogen , oncovirus , in vitro , tumor virus , cell culture , dna , microbiology and biotechnology , mesocricetus , cancer , genetics
Abstract Electron microscopic examination of many Syrian hamster cell cultures and of tumours induced in hamsters by oncogenic viruses revealed the presence of virus‐like particles (HVLP). A survey of many lines of hamster cells in primary cultures derived from various tissues of this animal did not show any H VLP. BHK 21/13, tumours induced by the injection of these cells and eleven different clones of BHK 21 transformed in vitro by RNA or DNA oncogenic viruses, contain different amounts of HVLP. These HVLP are associated with A‐type particles in clones transformed by Rous sarcoma virus. Previously published electron microscopic studies of spontaneous tumours induced by different agents (oncogenic viruses, chemical carcinogens, human cancer extracts) have frequently revealed the presence of the same H VLP. These studies permit some conclusions: (a) H VLP are morphologically distinct from other viral particles; (b) Syrian hamster could be the elective host; (c) the BHK 21 strains and derived clones contain this H VLP; and (d) carcinogenic agents seem to enhance the appearance of those viruses in hamster cells.