Premium
Cellular reactions against Burkitt lymphoma cells. III. Effector cell activity of leukocytes stimulated in vitro with autochthonous cultured lymphoma cells
Author(s) -
Golub Sidney H.,
Svedmyr Erik A. J.,
Hewetson John F.,
Klein George,
Singh Surjit
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100121
Subject(s) - lymphoma , lymphoblast , cytotoxic t cell , in vitro , immunology , burkitt's lymphoma , cell culture , biology , stimulation , peripheral blood , effector , cancer research , endocrinology , biochemistry , genetics
Peripheral blood leukocytes from four patients with Burkitt's lymphoma (BL) were studied for immunological reactions with lymphoblastoid culture line cells. In all four cases peripheral blood leukocytes could reproducibly be stimulated with autochthonous cultured cells derived from tumor biopsies. Stimulation could be accomplished despite the inability of the unstimulated lymphocytes to mediate a cytotoxic response. Leukocytes which have been stimulated with the autochthonous cells displayed strong colony inhibiting activity against the autochthonous BL‐derived target cell, but considerably less activity against two non‐BL‐derived target cells. Autochthonous fibroblasts were ineffective as stimulator cells.