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The specificity of surface membrane immunofluorescence in human malignant melanoma
Author(s) -
Lewis M. G.,
Phillips T. M.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100114
Subject(s) - immunofluorescence , melanoma , indirect immunofluorescence , lymphoma , pathology , reactivity (psychology) , virus , cytotoxicity , malignant cells , in vitro , medicine , immunology , biology , cancer research , antibody , cancer , biochemistry , alternative medicine
A study of membrane immunofluorescence on human malignant melanoma cells confirms previous preliminary reports indicating lack of significant cross‐reactivity with other melanoma sera, similar to that described in chemical carcinogen induced tumours. The importance of careful and critical appraisal of this technique is emphasized, and is supported by several other test systems, including cytotoxicity, demonstrating lack of cross‐reactivity. Multiple cross‐reactions with EB 3 virus‐infected Burkitt lymphoma cells and glandular fever sera were clearly seen using the same methods of immunofluorescence and interpretation.