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Effect of host strain and H‐2 type on spontaneous regression of murine leukemia
Author(s) -
Dietz Michael,
Rich Marvin A.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910100113
Subject(s) - leukemia , biology , virus , locus (genetics) , regression , strain (injury) , virology , murine leukemia virus , allele , immunology , genetics , psychology , gene , anatomy , psychoanalysis
Abstract The susceptibility of 14 mouse strains to a regressing and a conventional strain of Friend leukemia virus was studied. A comparison of leukemia incidence and latent period to leukemia development demonstrated that, for all mouse strains, the susceptibility to both viruses was the same. Leukemia regression occurred in 10 of the 12 mouse strains susceptible to regressing Friend virus (RFV). Regression of leukemia in mice inoculated with conventional Friend Virus (CFV) occurred primarily in those mouse strains homozygous for the H‐2 k allele. RFV‐induced leukemia regression was observed in mice homozygous for H‐2 a , H‐2 q , H‐2 s , H‐2 d , and H‐2 k . The H‐2 locus does not appear to be a determinant in leukemia regression.