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Immunisation contre la tumeur a virus sv40; importance de la voie d'inoculation
Author(s) -
Dubreuil R.,
Difranco Et E.,
Pavilanis V.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910090222
Subject(s) - heterologous , homologous chromosome , virus , inoculation , virology , transplantation , medicine , tumor cells , biology , immunology , cancer research , biochemistry , gene
Adult Syrian hamsters were vaccinated with SV40 virus or with SV40 virus‐transformed cells (heterologous or gamma‐irradiated homologous cells) by the subcutaneous and intraperitoneal routes; this increases the resistance of the animals against subsequent transplantation of tumor cells. However, there was a much greater proportion of animals that developed tumors in those injected by the i.p. route, this being the case not only for the vaccinated groups but also for the control groups. The injection of SV40‐transformed cells (heterologous or irradiated homologous cells) after the excision of transplanted tumors influenced the development of tumor recurrences and metastases. Here again, the treatment by the i.p. as compared to the s.c. route, was followed by a markedly higher rate of recurrences in the immunized as well as in the control groups. The treatment by the s.c. route appears to affect primarily tumor recurrences and regional metastases, while the treatment by the i.p. route inhibits the development of later metastases, especially lung metastases.