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Cell‐mediated responses to tumour xenografts in mice
Author(s) -
Simpson Elizabeth,
Beverley P. C. L.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910090207
Subject(s) - spleen , cytotoxic t cell , lymph , lymph node , pathology , neoplasm , immunity , ratón , biology , medicine , immunology , immune system , in vitro , biochemistry
A micro‐cytotoxic assay has been used to follow the course of the cell‐mediated response to a tumour xenograft in normal and ALS‐treated mice. In normal mice a peak response was seen at day 10 in both lymph nodes and spleen. Further peaks of cytotoxic activity were seen at days 18 and 42 in the spleen. In ALS‐treated mice, in which the tumour grew progressively, the response was slightly delayed in both lymph nodes and spleen. Subsequently 10 out of 12 mice bearing progressively growing tumours, tested at times up to 83 days after tumour grafting, showed immunity in either lymph nodes, spleen or both.