Premium
Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate
Author(s) -
Bansal S. C.,
Hargreaves R.,
Sjögren H. O.
Publication year - 1972
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910090112
Subject(s) - in vitro , cytotoxicity , blocking (statistics) , immunity , sarcoma , lymphocyte , cancer research , biology , immunology , immune system , pathology , medicine , biochemistry , statistics , mathematics
It has been shown previously that sera of tumor‐bearing individuals are capable of blocking specifically the lymphocyte cytotoxicity in vitro against the tumor cells in question. The present investigation demonstrates that blocking material, in the form of sera of rats carrying progressively growing polyoma tumors and low p H eluates of polyoma tumor tissue inoculated into polyoma isografted rats, cause an enhanced tumor growth. Corresponding serum from rats carrying an MCA‐induced sarcoma and eluate from such tumor tissue had no significant enhancing effect. The administered blocking activity was detectable in the sera of the recipients for 3 days after inoculation. No delay or decrease in the level of cell‐mediated anti‐tumor immunity could be detected by in vitro tests for lymphocyte cytotoxicity against polyoma tumor cells. This indicates that the mechanism of the facilitated tumor growth in vitro is akin to a central or an efferent type of enhancement.