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In vivo and in vitro recovery of defective friend virus by various leukemia viruses
Author(s) -
Fieldsteel A. Howard,
Dawson Peter J.,
Kurahara Carole
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910080216
Subject(s) - virus , virology , friend virus , leukemia , biology , in vivo , in vitro , viral transformation , murine leukemia virus , oncovirus , immunology , genetics
Friend virus‐induced reticulum cell sarcomas afler growth in tissue culture were shown to be free from infectious virus. Retrieval of infectious Friend virus could be accomplished with the aid of Moloney leukemia virus, Graffi leukemia virus, and the lymphatic leukemia virus associated with Friend virus, using both in vivo and in vitro techniques. On initial isolation, the pseudotypes differed from original Friend virus in their markedly reduced ability to induce Friend disease in other than newborn BALB/c mice. It was concluded that, although Friend virus may also exist in a non‐defective form, there was no evidence that the tumors contained other than helper‐dependent virus.