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Effect of host sex and splenectomy on moloney virus‐induced sarcomas
Author(s) -
Pollack Sylvia B.
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910080211
Subject(s) - splenectomy , spleen , immune system , sarcoma , virus , biology , immunology , medicine , pathology , cancer research
Female BALB/c mice injected intramuscularly with Moloney sarcoma virus (MSV) developed tumors which were smaller and were rejected more quickly than those induced in age‐matched males. Tumor rejection was also more frequent in splenectomized hosts than in sham‐operated controls. The eject of splenectomy was more pronounced in females than in males. In sub‐lethally irradiated mice challenged with MSV, sex‐related and spleen‐dependent differences in response to adoptively transferred spleen cells were observed. In females, both splenectomized and sham‐operated recipients of immune cells rejected their primary sarcomas, while the tumors grew rapidly in all recipients of normal cells. In a concurrent experiment with males, splenectomy had a greater suppressive effect on tumor growth than did the type of spleen cells tranferred (immune vs. normal).