Premium
Low molecular weight dextran and experimental metastasis growth
Author(s) -
Hagmar Björn
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910080207
Subject(s) - dextran , metastasis , suspension culture , lung , cell , pathology , medicine , subcutaneous injection , biology , cell culture , cancer research , cancer , biochemistry , genetics
The effect of low molecular weight dextran (LMD; M 4 × 10 4 ) was tested on intravenously‐induced metastases in a syngeneic tumour‐host system in mice. When given as intravenous pretreatment LMD increased the total number of gross extra‐pulmonary metastases, without significantly changing the planimetrically estimated lung and liver metastases. When, on the other hand, the same volume of LMD was given in the cell suspension, there was a further increase in gross extrapulmonary metastases and also in pulmonary metastases. There was an interesting parellelism between these results and the effect of cell and systemic treatment with LMD on the subcutaneous transplantability of tumour cells. Both types of treatment increased the frequency of subcutaneous takes but cell pretreatment with LMD alone increased resulting tumour volumes. The effects of LMD were not reflected in any alteration of the viability index in dye exclusion test or in the aggregability of the tumour cells.