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Serum factors in tumor‐free patients cancelling the blocking of cell‐mediated tumor immunity
Author(s) -
Hellström Ingegerd,
Hellström Karl Erik,
Sjögren Hans Olov,
Warner Glenn A.
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910080202
Subject(s) - immune system , immunity , cell mediated immunity , blocking (statistics) , tumor cells , melanoma , medicine , breast carcinoma , lymphocyte , cancer , immunology , cellular immunity , cancer research , carcinoma , pathology , breast cancer , statistics , mathematics
Abstract It has been previously shown that lymphocytes from cancer patients can kill cultivated neoplastic cells of the type carried by the lymphocyte donors and that sera from patients with growing tumors of the respective types can specifically block the tumor‐cell destruction. The present study demonstrates that sera from all of seven tumor patients tested (one with melanoma, one with colonic carcinoma and four with breast carcinoma), who had become clinically tumor‐free, could “unblock” ( = abrogate) the blocking effect of sera from patients bearing tumors of the respective types, thus making it possible for immune lymphocytes to kill cultivated neoplastic cells in the combined presence of the “unblocking” and blocking sera.