Premium
Studies on the relationship between thymus regeneration and lymphoma prevention in c57bl/6 mice irradiated and injected with syngeneic spleen cells
Author(s) -
Chen Louise
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910070315
Subject(s) - spleen , haematopoiesis , bone marrow , lymphoma , regeneration (biology) , biology , thymidine , neoplasm , immunology , cancer research , pathology , stem cell , medicine , microbiology and biotechnology , in vitro , biochemistry
Abstract Adult syngeneic spleen cells, which protect against radiogenic lymphoma, failed to induce thymus recovery after irradiation. However, bone‐marrow cells, which afford the same protection against lymphoma induction, are effective in promoting thymus regeneration. Similar observations were made in the experiments on incorporation of 3 H‐thymidine and 14 C‐phenyl alanine into thymuses of mice irradiated and injected with spleen or bone‐marrow cells. It appears that there are two different factors by which haematopoietic cells independently promote thymus regeneration and prevent lymphoma induction.