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Deoxyribonucleic acid polymerase associated with feline leukemia and sarcoma viruses: Properties of the enzyme and its product
Author(s) -
RoyBurman P.
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910070306
Subject(s) - feline leukemia virus , biology , dna polymerase , dna , polymerase , virology , sarcoma , virus , enzyme , polymerase chain reaction , leukemia , microbiology and biotechnology , biochemistry , genetics , pathology , medicine , gene
Native calf thymus and salmon sperm DNA are better templates than denatured calf thymus and salmon sperm DNA for the DNA‐dependent DNA polymerase activity of feline sarcoma virus. This enzyme activity of feline sarcoma virus and feline leukemia virus faithfully replicates dAT copolymer to synthesize a sequence of alternate deoxyadenylate‐deoxythymidylate. With a homopolymeric duplex, polydA.dT, the DNA‐directed enzyme from feline sarcoma virus or feline leukemia virus indicates a requirement for simultaneous copying of both template strands.