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The effect of polyinosinic: Polycytidylic acid on fluorescent and neutralizing antibodies to herpesvirus saimiri in goats
Author(s) -
Fraser C. E. O.,
Meléndez L. V.,
Barahona H. H.,
Daniel M. D.
Publication year - 1971
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910070304
Subject(s) - antibody , virology , fluorescence , biology , neutralizing antibody , primary and secondary antibodies , microbiology and biotechnology , immunology , physics , quantum mechanics
Goats are the best species so far tested for the preparation of fluorescent and neutralizing antibodies to Herpesvirus saimiri. Fluorescent antibodies to Herpesvirus saimiri seem to be different to neutralizing antibodies and polyinosinic: polycytidylic acid (poly I: C) may be of value in separating these two activities. Primary response fluorescent antibodies stained infected monolayers in a characteristic pattern, which is different from that of secondary response antibodies. The immunological and epidemiological implications of this are discussed.