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Lethal reticuloproliferative disease induced in Cebus albifrons monkeys by Herpesvirus saimiri
Author(s) -
Meléndez L. V.,
Hunt R. D.,
Daniel M. D.,
Fraser C. E. O.,
García F. G.,
Williamson M. E.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060314
Subject(s) - spleen , biology , pathology , inoculation , virology , lymph , lymph node , immunology , medicine
Four cinnamon ringtail monkeys (Cebus albifrons) inoculated intramuscularly with Herpesvirus saimiri died between 18 and 20 days after inoculation. Each of the four monkeys presented an extensive infiltration of reticulum cells in various organs (liver, lungs, kidney, pancreas, spleen, thymus, lymph node). The character of the infiltrate closely resembled reticulum cell sarcoma thus providing further evidence of the high oncogenic capacity of Herpesvirus saimiri.