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Humoral responses to tumour xenografts in ALS‐treated mice
Author(s) -
Beverley P. C. L.,
Simpson Elizabeth
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060312
Subject(s) - antibody , humoral immunity , hamster , medicine , antibody response , ratón , immunology , biology , pathology
An isotopic antiglobulin technique was used to study the humoral response to a hamster tumour grafted into ALS‐treated or normal mice. Approximately 50% of ALS‐treated animals fail to reject the tumour after cessation of ALS treatment. All ALS‐treated animals show a delayed humoral response compared to controls but in those animals which fail to reject tumours, a high level of serum antibody is maintained even in the presence of a large tumour mass.