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Transplantation immunity following immunization with extracts of adenovirus 12 tumour cells
Author(s) -
Potter C. W.,
Oxford J. S.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060311
Subject(s) - immunity , transplantation , hamster , immunization , antigen , centrifugation , biology , virology , virus , adenoviridae , immunology , microbiology and biotechnology , medicine , immune system , genetic enhancement , biochemistry , gene
Extracts were prepared from transplanted adenovirus‐12 tumours of both hamsters and CBA mice by freezing and thawing and centrifugation at 100,000 x g/1 h. Extracts from CBA mice were also filtered through Millipore filters. These extracts were found to induce immunity to tumour cell challenge. Immunization with similar extracts of hamster tumours induced by SV40 of CELO virus did not induce immunity in CBA mice to tumour development. The results indicate that a possibly soluble extracts of adenovirus 12 tumour transplantation antigen can be obtained, and this antigen can be assayed in the adenovirus‐12‐induced CBA mouse tumour system.