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Demonstration of antigens related to colonic cancer in the human digestive system
Author(s) -
Martin F.,
Martin M. S.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060305
Subject(s) - carcinoembryonic antigen , antigen , precipitin , saline , colonic cancer , cancer , colonic carcinoma , colorectal cancer , rectum , biology , pathology , medicine , immunology , gastroenterology , carcinoma
Heteroimmunization of rabbits with saline or perchloric extracts of colonic cancers permits the detection of two cancer‐related antigens. These antigens may be demonstrated, by direct precipitin reaction, in saline extracts of colonic or rectal adenocarcinomata, of some gastric cancers, and of foetal gut, but not in saline extracts of the non‐cancerous adult digestive system. However, precipitin‐inhibition reaction shows these antigens in perchloric extracts of non‐cancerous colonic mucosa but their concentration is much weaker than in intestinal tumours. Detection of a small amount of these antigens in non‐cancerous colonic mucosa implies that they are cancer‐related, but not cancer‐specific. Identity of one of the antigens with Gold's carcinoembryonic antigen is discussed.