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Upper respiratory tract tumors induced in syrian hamsters by N‐methyl‐N‐nitrosourea
Author(s) -
Herrold Katherine McD.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060208
Subject(s) - respiratory tract , pharynx , larynx , medicine , esophagus , respiratory system , pathology , carcinogen , epidermoid carcinoma , respiratory disease , hamster , gastroenterology , carcinoma , lung , anatomy , biology , genetics
Syrian hamsters were treated weekly for 2 1/2 months by intratracheal instillation of N‐nitroso‐N‐methylurea (NMU). All the animals, with the exception of one that survived to 11 months of age, were killed between 5 and 7 months because of severe respiratory insufficiency. Tumors, often multicentric in origin and frequently at different sites, developed in the nasopharyngeal tube, pharynx, larynx, trachea, bronchi, esophagus and forestomach. Histologically the tumors were epidermoid carcinomas. No distant metastases were observed. The results indicate that NMU exerts a strong local carcinogenic action when applied topically to the mucosa of the upper respiratory tract of Syrian hamsters. The wide spectrum of lesions, benign and malignant tumors, that occur following parenteral administration of NMU were not seen.