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Tumor induction with single urethan injection in newborn and adult syrian golden hamsters. A study on age influence. I.
Author(s) -
Toth B.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060110
Subject(s) - golden hamster , syrian hamsters , physiology , body weight , medicine , biology , hamster
Single subcutaneous injections of 1 mg urethan per g body weight were administered to newborn and 8‐week‐old randomly bred Syrian golden hamsters. The treatment ersulted in the induction of higher numbers of forestomach papillomas in animals receiving urethan at adult age than or birth. It gave rise to similar incidences of dermal melamocytomas inthe ovo age groups. Other tumors were also observed in the animals. Since only a few were seen of each type, it is difficult to relate their appearnace to the treatments. It is concluded that ageplays a role inh the oncogenic response of golden hamsters challenged by a single chemical stimulus. The ersults aer discussed in the light of previous studies performed in this field.