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Type‐C particles in human tissues. II. Electron microscopic study of embryonic cultures infected with a murine leukemia virus
Author(s) -
Chandra S.,
Stephens R.,
Wright B. S.,
Korol W.,
Zelljadt I.,
Jensen E. M.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910060108
Subject(s) - budding , endoplasmic reticulum , murine leukemia virus , virus , leukemia , biology , embryonic stem cell , virology , extracellular , virus like particle , tissue culture , cell type , cell , microbiology and biotechnology , in vitro , immunology , biochemistry , recombinant dna , gene
Type‐C virus particles are synthesized by cells from a number of human embryonic cultures infected with the Rauscher murine leukemia virus (RV). These particles have the characteristic morphology of the murine leukemia viruses. In some cultures, type‐C particles were also observed budding into the cisternae of rough endoplasmic reticulum of a few cells. Virus particles in the vicinity of such cells were of “immature” type. In contrast, particles in the vicinity of those cells which did not synthesize intracisternal type‐C particle were of the “mature” type. It is not known if the “mature” intracisternal particles have the morphology of the “mature” extracellular type‐C particles.