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Distribution of bound tritium from 3 h‐diethylnitrosamine in rat tissues
Author(s) -
Rajewsky M. F.,
Dauber W.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910050313
Subject(s) - carcinogen , nitrosamine , spleen , kidney , chemistry , kinetics , tritium , half life , radiochemistry , distribution (mathematics) , medicine , endocrinology , biochemistry , pharmacokinetics , biology , mathematical analysis , physics , mathematics , quantum mechanics , nuclear physics
The concentration of bound 3 H from diethyl‐(mono‐2‐ 3 H)‐nitrosamine was determined in five different rat tissues as a function of time after single and repeated oral doses of the labelled carcinogen. The recorded curves can be described as two‐component kinetics. Whereas the first component decreased with a half‐life of about 3–6 h, the corresponding value for the second component was approximately 90 h. Two hundred and forty hours after a single 3 H‐DEN dose, the highest relative concentration of bound 3 H was recorded in the liver (1.00), followed by kidney (0.74), spleen (0.40), small intestine (0.18), and lung (0.14). The capacity of the liver to metabolically activate DEN, as reflected by the tissue‐specific accumulation of bound 3 H after repeated 3 H‐DEN doses, was not impaired at an advanced stage of hepatocarcinogenesis by DEN.