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Absence of thymic involvement in the inhibition of urethan lung adenomagenesis by X‐radiation
Author(s) -
Bartlett Gerald L.
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910050312
Subject(s) - lung , pathology , cancer research , inhibitory postsynaptic potential , medicine , chemistry , biology
Since regional thoracic irradiation involves the thymus, as well as lung tissue, inhibition of urethan lung adenomagenesis by thoracic irradiation might be mediated by radiation damage to the thymus. This paper reports experiments which show that lung tumor induction is not inhibited by surgical removal of the thymus and that the inhibitory effect of radiation is not reversed by grafts of normal thymus tissue. Hence, the thymus is not essential to pulmonary adenomagenesis, and does not mediate the inhibitory effect of radiation.