Effect of withaferin a on ehrlich ascites tumor cells — cytological observations | Zendy

Shohat Batia | Zendy; Gitter Simon | Zendy; Lave David | Zendy

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Effect of withaferin a on ehrlich ascites tumor cells — cytological observations

Author(s) -

Shohat Batia,

Gitter Simon,

Lave David

Publication year - 1970

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910050212

Subject(s) - withaferin a , ehrlich ascites carcinoma , metaphase , ehrlich ascites , withania somnifera , mitosis , ascites , biology , tumor cells , pharmacology , cancer research , pathology , biochemistry , medicine , microbiology and biotechnology , alternative medicine , chromosome , gene

Withaferin A, a steroidal lactone with carcinostatic properties, isolated from the leaves of Withania somnifera Dun., produced a mitotic arrest in the metaphase of dividing Ehrlich ascites carcinoma cells. In addition this compound also induced vacuolization of the cytoplasm. A single dose of withaferin A, administered 24 hours after Ehrlich ascites implantation, caused growth reduction followed by disappearance of the tumor in 80% of the mice. These mice were found to be resistant to rechallenge with Ehrlich ascites tumor cells. The inhibition of Ehrlich ascites tumor growth is thought to represent a combined effect of withaferin A action and immune reactions.

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