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Effect of withaferin a on ehrlich ascites tumor cells — cytological observations
Author(s) -
Shohat Batia,
Gitter Simon,
Lave David
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910050212
Subject(s) - withaferin a , ehrlich ascites carcinoma , metaphase , ehrlich ascites , withania somnifera , mitosis , ascites , biology , tumor cells , pharmacology , cancer research , pathology , biochemistry , medicine , microbiology and biotechnology , alternative medicine , chromosome , gene
Withaferin A, a steroidal lactone with carcinostatic properties, isolated from the leaves of Withania somnifera Dun., produced a mitotic arrest in the metaphase of dividing Ehrlich ascites carcinoma cells. In addition this compound also induced vacuolization of the cytoplasm. A single dose of withaferin A, administered 24 hours after Ehrlich ascites implantation, caused growth reduction followed by disappearance of the tumor in 80% of the mice. These mice were found to be resistant to rechallenge with Ehrlich ascites tumor cells. The inhibition of Ehrlich ascites tumor growth is thought to represent a combined effect of withaferin A action and immune reactions.