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Colony inhibition studies on blocking and non‐blocking serum effects on cellular immunity to moloney sarcomas
Author(s) -
Hellström Ingegerd,
Hellström Karl Erik
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910050205
Subject(s) - blocking (statistics) , virus , inoculation , biology , immunity , immunology , sarcoma , lymph node , virology , ratón , inhibitory postsynaptic potential , lymph , immune system , medicine , pathology , endocrinology , statistics , mathematics
Moloney‐virus‐induced sarcomas, originating in BALB/c and A/Sn mice, were studied with the colony inhibition (CI) assay. Mice inoculated with the virus as adults developed tumors which spontaneously regressed (regressors) while mice inoculated with the same virus dose at an age of 21 days or less died from progressively growing tumors (progressors). Serum from progressors blocked the colony inhibitory effect of lymph‐node cells (LNC) from the regressors. Serum from mice inoculated with the virus as adults had a similar blocking effect as long as the mice carried progressively growing tumors, but it did not block the LNC effect when harvested at the onset of regression or after its completion. When regressor sera were mixed with progressor sera the blocking effect of the latter decreased.