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Effect of azathioprine on the chromosome complement of human bone marrow cells
Author(s) -
Jensen Mogens Krogh
Publication year - 1970
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910050119
Subject(s) - azathioprine , chromosome , bone marrow , immunology , complement (music) , biology , bone marrow transplant , cancer research , medicine , pathology , bone marrow transplantation , genetics , disease , phenotype , complementation , gene
Chromosome studies were performed on bone marrow aspirates from 15 patients treated with azathioprine. In most patients the immunosuppressive therapy produced structural changes of the chromosome complement. The structural chromosome aberrations disappeared after cessation of therapy. In four patients no evidence of chromosome abnormalities could be found during therapy with azathioprine. It is proposed that the study of bone marrow cells may be more important than that of short‐term leukocyte cultures when estimating the chromosome damaging properties of some chemical agents.