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Malignant and transforming activity of rous sarcoma virus. I. Malignant effect of rous sarcoma virus
Author(s) -
Obukh I. B.,
Kryukova I. N.,
Biryulina T. I.,
Kuznetsova N. N.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040608
Subject(s) - rous sarcoma virus , sarcoma , virology , virus , biology , strain (injury) , antigen , immunology , pathology , medicine , anatomy
Cultures of cells from embryos of Af, C3H‐H p/2 and (CBAT6T6 × Af)F 1 mice rapidly developed oncogenicity for syngeneic animals after exposure to RSV (Carr‐Zilber strain). The tumours of mice were virogenic and contained the group‐specific antigen of avian sarcoma‐leukosis complex. However, when the infected cells became transformed in morphology, they lost their oncogenicity for syngeneic animals.