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Inactivation of an x‐irradiated tumor by independent processes in in vivo
Author(s) -
Maruyama Yosh,
Ackerman Eugene,
Khan Faiz M.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040607
Subject(s) - in vivo , lymphoma , irradiation , cancer research , cell , tumor cells , radiation therapy , biology , biophysics , chemistry , immunology , medicine , genetics , physics , nuclear physics
An inactivation model is postulated for tumor‐cell radiation response in vivo based upon the response to multiple independent processes. These are intrinsic cell radiation response (Process 1), and immunological host resistance (Process 2). A composite dose‐effect relationship which arises is described. Experimental data found with the LSA mouse lymphoma are analyzed and show agreement with the model proposed.