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Chromosomal analysis of some transplanted tumors induced by 3‐methylcholanthrene in golden hamsters
Author(s) -
Popescu N. C.,
Cioloca Lidia,
Liciu Florentina,
Encut I.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040606
Subject(s) - biology , karyotype , ploidy , population , chromosome , methylcholanthrene , chromosomal analysis , transplantation , cytogenetics , chromosome abnormality , marker chromosome , pathology , microbiology and biotechnology , genetics , carcinogen , medicine , gene , environmental health
Three primary tumors induced by 3‐MCA in the golden hamster, with a diploid chromosome constitution and a short latency period, were allogeneically transplanted. Three tumor lines with a total of 19 individual transplanted tumors were chromosomally analyzed. None of the originally diploid tumors preserved its chromosomal constitution in allogeneic serial transplantation. A model of heteroploid transformation was established. In two tumor lines the presence of host cells was observed and in one line at advanced passages a new tumor‐cell population occurred with multiple severe chromosomal aberrations derived from the host cells. No specific chromosomal changes could be observed, but each line was characterized by chromosomal markers and a non‐random distribution in some chromosome groups was identified. The spontaneous occurrence of chromosomal aberrations with a very high incidence occurring in the host cells at advanced passages could not be accounted for by direct action of the chemical substance and possible secondary factor/s of a viral or metabolic nature are discussed.