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Infectious but non‐leukemogenic friend leukemia virus obtained after prolonged cultivation in vitro
Author(s) -
Yoshikura H.,
Hirokawa Y.,
Ikawa Y.,
Sugano H.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040508
Subject(s) - virology , in vitro , infectivity , biology , leukemia , virus , strain (injury) , oncovirus , neoplasm , murine leukemia virus , immunology , genetics , anatomy
A non‐leukemogenic strain of Friend leukemia virus (FLV) propagated in vitro interfered with infection by murine sarcoma virus (Moloney) (MSV) and acted as a helper of defective MSV. This suggests that the non‐leukemogenic strain of FLV is infectious. After prolonged propagation in vitro , the leukemogenicity of a highly leukemogenic strain of FLV gradually decreased, while the infectivity assayed by interference with MSV infection remained unchanged.