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Studies on serum‐mediated inhibition of cellular immunity to spontaneous mouse mammary tumors
Author(s) -
Heppner G. H.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040505
Subject(s) - mammary tumor , in vivo , in vitro , lymph node , sarcoma , immunity , mouse mammary tumor virus , cancer research , neoplasm , biology , mammary gland , tumor cells , cellular immunity , immunology , virus , immune system , pathology , medicine , cancer , genetics , microbiology and biotechnology , breast cancer , biochemistry
Sera from mice which have either spontaneously developed a mammary tumor, or which have been immunized against such a tumor, have been shown capable of abrogating the ability of lymph‐node cells from these mice to specifically inhibit colony formation by mammary tumor cells in vitro . Sera from mice sensitized to another, independently arising, syngeneic mammary tumor or to a syngeneic Moloney sarcoma virus‐induced tumor are less active in this respect, indicating that this reaction is specific. It is suggested that these observations are related to the in vivo phenomenon called immunological enhancement.