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Aflatoxin carcinogenesis: Inhibition of liver cancer induction in hypophysectomized rats
Author(s) -
Goodall C. M.,
Butler W. H.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040407
Subject(s) - aflatoxin , hypophysectomy , carcinogen , medicine , endocrinology , carcinogenesis , biology , cancer , toxicity , biochemistry , hormone , food science
Intact and hypophysectomized male rats were fed aflatoxin at a dose (4 μg/g in diet) sufficient to produce liver cancers in all of the 14 intact rats surviving 49 weeks. Fourteen hypophysectomized rats also survived this latent period, but no liver tumors were induced although the animals received aflatoxin at a higher rate than the intact control animals. However, tumors of extrahepatic tissues—particularly of the retro‐orbital lacrimal glands—were induced in the hypophysectomized rats. The selective blockade of hepatocarcinogenesis by hypophysectomy previously known with aminoazo dyes and fluorenamines is therefore extended to a new class of chemicals, the aflatoxins. It is suggested that aflatoxins may require metabolic activation before becoming effective carcinogens for rat liver.