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Disappearance of infectious virus from friend virus‐induced C57BL/6 tumors
Author(s) -
Odaka Takeshi,
Ikawa Yoji,
Takizawa Kiyoshi
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040405
Subject(s) - hepatosplenomegaly , virus , friend virus , spleen , murine leukemia virus , lymph node , virology , biology , transplantation , neoplasm , pathology , mesenteric lymph nodes , lymphoma , c57bl/6 , immunology , medicine , surgery , disease
Mice of C57BL/6 strain which had been infected with Friend leukemia virus within 15 days after birth developed hepatosplenomegaly after a latent period of about 2 months. Without exception, the enlarged spleens of these diseased mice contained infectious virus. Isografts from 13 such spleens gave rise to 5 transplantable lymphomas. These 5 tumors were all derived from the mice with enlarged thymus and/or mesenteric lymph node, while no tumors were obtained from spleen grafts from the mice with non‐enlarged thymus and node. The tumors thus established were passed successively in solid form in C57BL/6 mice. They lost demonstrable virus within a few, at most 9, passages in syngeneic mice. With these characteristics, these tumors are unique among Friend tumors of murine origin, since all thus far reported contained readily demonstrable virus. The presence of virus‐specific transplantation antigens was confirmed in some of these tumors. The induction of lymphoblastic lymphomas by Friend virus in C57BL/6 mice was discussed.