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Cross‐reacting tstas in adeno 7 and 12 tumors demonstrated by 51 C R ‐Cytotoxicity and isograft rejection tests
Author(s) -
Ankerst Jaro,
Sjögren Hans O.
Publication year - 1969
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910040305
Subject(s) - hamster , isograft , cytotoxic t cell , cytotoxicity , biology , microbiology and biotechnology , transplantation , chinese hamster , cancer research , immunology , cell culture , medicine , in vitro , biochemistry , genetics
Antisera of mice hyperimmunized against syngeneic X‐irradiated adeno 12 tumor cells were tested for complement‐dependent cytotoxicity against an adeno 7 and an adeno 12 hamster tumor by a 51 Cr‐cytotoxic test, developed to work on non‐lymphoid target cells. Significant isotope release above the level of release obtained after exposure to control sera was recorded with both tumors. There was no similar release from BHK‐C13 control hamster cells. The cytotoxic effect on hamster adeno 7 tumor cells was confirmed by the colony inhibition technique. Furthermore, it was demonstrated by transplantation tests in mice that the hamster adeno 7 tumor cells were immunogenic, causing an isograft immunity to adeno 12 tumors similar to that induced by adeno 12 hamster and mouse tumor cells.