In vitro  demonstration of tumor‐specific antigens in spontaneous mammary tumors of mice | Zendy

Heppner G. H. | Zendy; Pierce G. | Zendy

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In vitro demonstration of tumor‐specific antigens in spontaneous mammary tumors of mice

Author(s) -

Heppner G. H.,

Pierce G.

Publication year - 1969

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910040211

Subject(s) - mammary tumor , lymph node , neoplasm , antigen , immune system , biology , immunity , mouse mammary tumor virus , in vitro , mammary gland , pathology , cancer research , immunology , cancer , virus , medicine , breast cancer , biochemistry , genetics

The colony‐inhibition test has been used to demonstrate cellular immunity against spontaneous murine mammary tumors, both in autochthonous, mammary tumor virus (MTV)‐carrying BALB/cfC3H and in immunized, MTV‐free, BALB/c mice. Immunity could be demonstrated in nearly all cases against a mammary tumor with lymph‐node cells from mice which had experienced that tumor. One of eight tumors tested with lymph‐node cells from BALB/cfC3H mice which had spontaneously developed mammary tumors showed evidence of immunological cross‐reactivity, while seven of thirteen tumors did so when tested with immune cells from MTV‐free BALB/c mice. The data, therefore, indicate the presence of at least two types of tumor‐specific antigen (s) in mouse mammary tumors — a common one and an antigen specific for each neoplasm.

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