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Effect of herpes simplex virus on human embryonic cells latently infected with reovirus type 3
Author(s) -
Bell Thomas M.,
Munube Germano M. R.,
Griffin E. R.
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030608
Subject(s) - virology , herpes simplex virus , virus , embryo , biology , simplexvirus , herpesviridae , embryonic stem cell , viral culture , viral disease , microbiology and biotechnology , gene , genetics
A persistent latent infection of human embryo fibroblasts by reovirus type 3 was found to be due to the continuous infection of a small proportion of the cells. Super‐infection of these cultures by herpes simplex virus resulted in the destruction of the monolayers by the herpes virus without any obvious signs of interference. Electron microscopic examination of these doubly infected cultures showed the presence of multi‐nuclear blebs and an unusual, “condensed‐mass”, form of intranuclear herpes virus. The implications of these findings are discussed.