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Auto‐antibody to 7,12‐dimethylbenz( A )anthracene‐induced leukemic cells in rats as detected by immune adherence
Author(s) -
Yoshida Takato O.,
Imai Kuniyuki,
Sugiyama Taketoshi
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030604
Subject(s) - antibody , immune system , hemagglutination , antigen , 7,12 dimethylbenz[a]anthracene , immunology , leukemia , biology , chemistry , medicine , dmba , carcinogenesis , cancer
Sixteen Long‐Evans rats with leukemias induced by 7,12‐dimethylbenz(a)anthracene were studied for evidence of naturally occurring immunologic responses to their own leukemic cells with an immune adherence hemagglutination technique which was designed to detect fresh serum auto‐antibodies to the membrane of the leukemic cells. Auto‐antibodies to the cell membranes were found in 14 out of 16 rats, but were not demonstrable in the other two rats. Autochthonous thymus cells used as controls did not show positive immune adherence hemagglutination reactions with their own sera, nor did the leukemic cells show positive reactions with the pooled normal rat serum. These findings suggest a possibility that the leukemic rats are able to produce humoral antibodies against membrane‐specific antigens of autochthonous leukemic cells.