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Accumulation of labelled vitamin B 12 in some transplanted tumours
Author(s) -
Flodh Hans,
Ullberg Sven
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030518
Subject(s) - ascites , pathology , mammary carcinoma , sarcoma , tumour tissue , biology , vitamin b12 , carcinoma , medicine , endocrinology
The accumulation of labelled vitamin B 12 in four different kinds of transplanted tumour was studied using whole‐body autoradiography and impulse counting. The tumours were 90 Sr‐induced soft fibroblastic osteosarcomas, spontaneous mammary carcinomas, Ehrlich ascites and Moloney virus‐induced tumours. The 90 Sr‐induced soft sarcoma, which was the most rapidly growing tumour, showed the greatest uptake of radio‐B 12 , the concentration being higher than in any normal tissue. In all tumours the radioactivity was localized to the peripheral, still actively growing parts. It is suggested that a connection exists between growth rate and accumulation of B 12 and that B 12 is needed for rapid cell multiplication.