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MODIFICATIONS DU MÉTABOLISME GLUCIDIQUE DANS LE FOIE EN VOIE DE CANCÉRISATION PAR LE DIMÉTHYLAMINOAZOBENZÈNE I. RECHERCHES AU NIVEAU DU CYCLE DU GLYCOGÈNE
Author(s) -
Meunier Michèle,
Jacob Arlette
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030406
Subject(s) - glycogen , phosphoglucomutase , glycogen phosphorylase , liver metabolism , chemistry , biochemistry , biology , enzyme
In an attempt to find an explanation for the hypoglycaemia observed in rats with DAB‐induced hepatomas, we studied glycogen metabolism in rat livers in which cancer invasion proceeded at different speeds. We measured the content of glycogen and of glucose‐6‐phosphate in the liver and determined the activities of glycogen‐synthetase, phosphorylase, and phosphoglucomutase. We demonstrated that the cause of the hypoglycaemia varies from one case to another. In some instances, glycogen accumulates in the liver but can no longer be broken down into glucose, while in others glycogen is no longer synthesized.