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Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicks
Author(s) -
Bliznakov Emile G.
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030303
Subject(s) - rous sarcoma virus , mononuclear phagocyte system , stimulation , biology , antiserum , virus , immunology , medicine , physiology , endocrinology , antigen
By using a non‐toxic reticuloendothelial system stimulant, lipid‐Restim, derived from shark livers, we were able to demonstrate the following effects on growing Rous sarcoma tumors in young chicks. Prechallenge Restim treatment: Significant reduction of the percentage of chicks with tumors and prolongation of the latent period resulted from combined administration of Restim and specific antiserum . Postchallenge Restim treatment: The mortality data indicated that there was a significant increase in survival time and survival rate. Complete regressions The term “regression” is used in this paper to mean complete macroscopical disappearance of the primary tumor at the site of inoculation of the virus. occurred in a significant number of the Restim‐treated chicks compared to the controls. Possible explanations of these findings are discussed.