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Effets de l'iodoacétamide sur les cellules de la leucémie virale de rauscher. Effects of iodoacetamide on cells of rauscher virus leukaemia
Author(s) -
Jasmin C.,
Piton C.,
Rosenfeld C.
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030210
Subject(s) - virus , in vitro , spleen , iodoacetamide , antigenicity , biology , virology , poxviridae , microbiology and biotechnology , antigen , vaccinia , immunology , biochemistry , cysteine , gene , enzyme , recombinant dna
Iodoacetamide reduces the leukaemogenic properties of the Rauscher leukaemia virus, by direct contact in vitro. Murine leukaemic spleen cells incubated for 1 hour at 37° C in vitro can immunize isogeneic mice against the Rauscher virus. The mechanism of action of this product is discussed: 1) action by direct contact on the leukaemogenic properties of the virus; 2) cellular toxicity of the product which modifies the viral reproduction by treated cells; 3) action on the antigenicity of the treated cells.