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Biological, pathological and physical characterization of a possible variant of a murine sarcoma virus (Moloney)
Author(s) -
Chirigos M. A.,
Scott D.,
Turner W.,
Perk K.
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030207
Subject(s) - virus , viremia , spleen , virology , sarcoma , biology , lymph , neoplasm , rhabdomyosarcoma , pathology , immunology , medicine , genetics
The biological characteristics of a sarcoma virus and the pathogenesis of the disease induced by it are described. The present agent was derived from a transplantable rhabdomyosarcoma originally induced by the murine sarcoma virus (Moloney). Splenomegaly and mean latent period to death of the host were found to be dependent upon initiating virus dose. Various dilutions of the virus inoculated by four different routes resulted in a high incidence of tumor induction, progressive splenomegaly and subsequent death of the recipients. Of six strains of adult mice tested, three, i.e., BALB/c, DBA/2, and Swiss, were found to be susceptible. All six strains were susceptible when inoculated as newborns. Splenomegaly and viremia were detected in adult BALB/c mice as early as 7 days after infection. Intraperitoneal virus inoculation of adult mice resulted in an early and progressive viremia, and neoplastic involvement of the spleen, lymph nodes, and striated musculature. The histological and ultra‐structural appearance of these tumors suggested that this neoplasm may be classified as an undifferentiated sarcoma. The biological characteristics and pathological changes occurring in animals inoculated with this virus are in certain respects similar, but not identical, to those of miceinoculated with Moloney and Harvey murine sarcoma virus isolates. Physical properties of the virus are discussed.